技术|单克隆抗体制备方法的前世今生( 三 )
[2]. Spieker-Polet H, Sethupathi P, Yam PC, Knight KL. Rabbit monoclonal anti-bodies: generating a fusion partner to produce rabbit-rabbit hybridomas. Proc Natl Acad Sci U S A (1995) 92:9348–52. doi:10.1073/pnas.92.20.9348
[3]. Olsson L, Kaplan HS. Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity. Proc Natl Acad Sci U S A (1980) 77:5429–31. doi:10.1073/pnas.77.9.5429
[4]. Lowe D, Jermutus L. Combinatorial protein biochemistry for therapeutics and proteomics. Curr Pharm Biotechnol (2004) 5:17–27. doi:10.2174/ 1389201043489585
[5]. Peterson NC. Advances in monoclonal antibody technology: genetic engineering of mice, cells, and immunoglobulins. ILAR J (2005) 46:314–9. doi:10.1093/ilar.46.3.314
[6]. Rader C, Ritter G, Nathan S, Elia M, Gout I, Jungbluth AA, et al. The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies. J Biol Chem (2000) 275:13668–76. doi:10.1074/jbc.275.18.13668
[7]. Knappik A, Ge L, Honegger A, Pack P , Fischer M, Wellnhofer G, et al. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides. J Mol Biol (2000) 296:57–86. doi:10.1006/jmbi.1999.3444
[8]. Rothe C, Urlinger S, Lohning C, Prassler J, Stark Y , Jager U, et al. The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies. J Mol Biol (2008) 376:1182–200. doi:10.1016/j.jmb.2007.12.018
[9]. Tiller T, Schuster I, Deppe D, Siegers K, Strohner R, Herrmann T, et al. A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties. MAbs (2013) 5:445–70. doi:10.4161/mabs.24218
[10]. Shim H. Synthetic approach to the generation of antibody diversity. BMB Rep (2015) 48:489–94. doi:10.5483/BMBRep.2015.48.9.120
[11]. Alt FW, Keith Blackwell T, Yancopoulos GD. Immunoglobulin genes intransgenic mice. Trends Genet. 1985;1:231–6.
[12]. Jakobovits A, Amado RG, Yang X, Roskos L, Schwab G. From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice. Nat Biotechnol. 2007;25:1134–43
[13]. Tiller T. Single B cell antibody technologies. N Biotechnol (2011) 28:453–7. doi:10.1016/j.nbt.2011.03.014 41.
[14]. Flego M, Ascione A, Cianfriglia M, Vella S. Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases. BMC Med (2013) 11:4. doi:10.1186/1741-7015-11-4
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