#猴子#CROI 2020：HIV治愈研究联盟产生了诱人的新数据( 四 ) |动物|艾滋病|艺术|

在小鼠实验中，给予一种CAR T细胞的动物因治疗中断而产生的病毒载量比对照组小鼠低2个对数（100倍）。
在CROI（Rust）上进行的一项研究中， 4只接受CAR T细胞的猴子在停药后经历了病毒反弹的延迟，其中一只在停药七周后仍未被发现。
在人体试验中，一旦注入CCR5耗尽和CAR T细胞的组合，一个组就可以停止其ART治疗。在另一组，抗逆转录病毒治疗的中断将延迟八周。
本文参考：
Watch Dan Barouch's video on YouTube.
Watch Jim C Riley's video on YouTube.
Abstracts presented at the main conference mentioned in this piece are as follows:
Barouch D et al. Combined active and passive immunization in SHIV-infected rhesus monkeys.Conference on Retroviruses and Opportunistic Infections, abstract 78, March 2020.
View the abstract on the conference website.
Watch the webcast on the conference website.
Prague M et al. Viral rebound kinetics following single and combination immunotherapy for HIV/SIV. Conference on Retroviruses and Opportunistic Infections, abstract 320, March 2020.
View the abstract on the conference website.
View the poster on the conference website.
SenGupta D et al. Safety and analytic treatment interruption outcomes of vesatolimod in HIV controllers. Conference on Retroviruses and Opportunistic Infections, abstract 40, March 2020.
View the abstract on the conference website.
Watch the webcast on the conference website.
Rust B et al. Chimeric antigen receptor T-cells control SHIV replication in post-ATI macaques. Conference on Retroviruses and Opportunistic Infections, abstract 76, March 2020.
View the abstract on the conference website.
Watch the webcast on the conference website.
来源：HIV最新动态
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