简单改变靶向药用法，效果居然好这么多( 三 ) 文|菠萝惊艳的三年总生存率在最近结束

正因为如此， ALK突变患者使用一种二代靶向药耐药后，仍可能从另一个二代靶向药中获益。比如，用阿来替尼后耐药的患者，如果基因检测发现是因为ALK基因的I1171N突变，那用塞瑞替尼还有可能使病症得到进一步治疗。反之亦然。
另一方面，要看患者对不同副作用的耐受度。
塞瑞替尼的副作用主要在胃肠道，比如腹泻，恶心等，阿来替尼则是肝脏和肾脏问题，表现为胆红素上升，血肌酐升高等。患者本来就有胃肠道或肝肾问题，医生可能会优先推荐对应副作用更小的药物。
特别高兴看到塞瑞替尼优秀的最新数据，参与的科学家们功不可没，肯定都很有成就感。
随着越来越多靶向新药的出现，未来ALK融合突变肺癌患者很多都可能活到5年，甚至7年以上。对于他们而言，癌症可能会变成一种慢性病，这对增强患者治疗信念、提高生存质量都是一种里程碑式的转变。相信会有更多的好消息，让“钻石”更加闪亮。
致敬生命！
*本文旨在科普癌症新药背后的科学，不是药物宣传资料，更不是治疗方案推荐。如需获得疾病治疗方案指导，请前往正规医院就诊。
参考文献：
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