镇静|【罂粟摘要】丙泊酚联合纳布啡在无痛宫腔镜检查中镇静作用的ED50 牛羊肉|癌症病人|果汁|肿瘤|癌

丙泊酚联合纳布啡在无痛宫腔镜检查中镇静作用的ED50

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贵州医科大学麻醉与心脏电生理课题组
翻译：邓举编辑：潘志军审校：曹莹
1
背景
纳布啡已逐渐成为临床上无痛宫腔镜检查的镇痛药物。我们研究的目的是确定丙泊酚联合纳布啡进行无痛宫腔镜检查的半数有效剂量(ED50)。
2
方法
我们招募了61例年龄在18-60岁之间的患者进行择期无痛宫腔镜检查。内镜置入前3分钟，（A组）患者静脉注射纳布啡0.1mg/kg,（B组）患者静脉注射纳布啡0.2mg/kg。采用Dixon序贯法，丙泊酚初始静脉注射剂量为2mg/kg，序贯变化剂量为0.5mg/kg。
3
结果
我们招募了61例年龄在18-60岁之间的患者进行择期无痛宫腔镜检查。内镜置入前3分钟，（A组）患者静脉注射纳布啡0.1mg/kg,（B组）患者静脉注射纳布啡0.2mg/kg。采用Dixon序贯法，丙泊酚初始静脉注射剂量为2mg/kg，序贯变化剂量为0.5mg/kg。

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【 镇静|【罂粟摘要】丙泊酚联合纳布啡在无痛宫腔镜检查中镇静作用的ED50】 4
结论
为了安全有效地进行无痛宫腔镜检查，联合纳布啡的丙泊酚ED50值分别为1.729mg/kg（0.1mg/kg纳布啡）和1.658mg/kg(0.2mg/kg纳布啡)。因此，纳布啡的推荐剂量为0.1mg/kg。
原始文献来源 ?
Chen Chen , Weixiang Tang , Wei Ye, et al. ED50 of Propofol Combined with Nalbuphine on the Sedative Effect in Painless Hysteroscopy. [J].Pain Ther (2021) 10:1235–1243.
英文原文
ED50 of Propofol Combined with Nalbuphine on the Sedative Effect in Painless Hysteroscopy
Abstract
A
Introduction:
Nalbuphine has gradually become a commonly used clinical analgesic
drug for painless hysteroscopy. The aim of our study was to identify the median effective dose (ED50) of propofol combined with nalbuphine for painless hysteroscopy.
B
Methods:
Sixty-one patients aged 18–60 years were recruited to undergo elective painless hysteroscopy. Patients were administered 0.1 mg/kg nalbuphine (group A) or 0.2 mg/kg nalbuphine (group B) intravenously 3 min before endoscopic placement. The Dixon sequential method was used with an initial intravenous propofol dose of 2 mg/kg, which varied by 0.5 mg per kilogram.
C
Results:
The ED50 of propofol was 1.729 mg/kg (95% confifidence interval [CI] 1.526–1.856 mg/ kg) in group A and 1.658 mg/kg (95% CI 1.359–1.799 mg/kg) in group B. The 95% effective dose (ED95) of propofol was 2.051 mg/kg (95% CI 1.899–3.331 mg/kg) in group A and 2.020 mg/kg (95% CI 1.849–3.832 mg/kg) in group B.
D
Conclusion:
For safety and effective painless hysteroscopic, the ED50 values of propofol combined with nalbuphine were 1.729 mg/kg (0.1 mg/kg nalbuphine) and 1.658 mg/kg (0.2 mg/kg nalbuphine). The recommended dose of nalbuphine is therefore 0.1 mg/kg.
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