降脂|上元佳节，事事皆圆：一个降脂原则将ASCVD发病延迟到100岁！( 二 ) 降脂|ascvd|冠心病|心血管

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图5 应尽早且长期保持低血脂水平
荟萃分析显示，因基因的影响长期处于低LDL-C暴露的患者，其获益是药物短期降脂治疗获益的3倍，且不同基因多态性介导的降低LDL-C的临床获益相当[7] 。
因此，彭道泉教授指出：“长期控制LDL-C比短期控制临床获益更大。 ”

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参考文献：
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[2] Ference BA, Ginsberg HN, Graham I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2017 Aug 21;38(32):2459-2472. doi: 10.1093/eurheartj/ehx144. PMID: 28444290; PMCID: PMC5837225.
[3] Ference BA. Mendelian randomization studies: using naturally randomized genetic data to fill evidence gaps. Curr Opin Lipidol. 2015 Dec;26(6):566-71. doi: 10.1097/MOL.0000000000000247. PMID: 26780009.
[4] Khera AV, Won HH, Peloso GM, et al. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016 Jun 7;67(22):2578-89. doi: 10.1016/j.jacc.2016.03.520. Epub 2016 Apr 3. PMID: 27050191; PMCID: PMC5405769.
[5] Ference BA, Graham I, Tokgozoglu L, Catapano AL. Impact of Lipids on Cardiovascular Health: JACC Health Promotion Series. J Am Coll Cardiol. 2018 Sep 4;72(10):1141-1156. doi: 10.1016/j.jacc.2018.06.046. PMID: 30165986.
[6] Domanski MJ, Tian X, Wu CO, et al. Time Course of LDL Cholesterol Exposure and Cardiovascular Disease Event Risk. J Am Coll Cardiol. 2020 Sep 29;76(13):1507-1516. doi: 10.1016/j.jacc.2020.07.059. PMID: 32972526.
[7] Ference BA, Yoo W, Alesh I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol. 2012 Dec 25;60(25):2631-9. doi: 10.1016/j.jacc.2012.09.017. Epub 2012 Oct 17. PMID: 23083789.
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