雌孕激素联合口服避孕药是致癌物吗
使用含孕激素及雌激素的联合口服避孕药,有轻微的致癌风险
这个在2007年,国际癌症研究机构对联合口服避孕药的研究报告\u0026amp;amp;amp;amp;amp;amp;amp;amp;quot;Combined Estrogen-Progestogen Contraceptives\u0026amp;amp;amp;amp;amp;amp;amp;amp;quot;中所指出。因其有增加患有乳腺癌的可能性,被列为1类致癌物。
举个例子:妈富隆的去氧孕烯炔雌醇片
因为含有:去氧孕烯(孕激素),炔雌醇(雌激素)
属于联合口服避孕药,故也有致癌可能性。
关于致癌风险,可参考下面来自维基百科的简要解释,大致意思为:服用联合口服避孕药可降低患卵巢癌、子宫内膜癌的风险,但是会轻微增加乳腺癌的患病几率。
【雌孕激素联合口服避孕药是致癌物吗】 COC decreased the risk of ovarian cancer, endometrial cancer, and colorectal cancer. Two large cohort studies published in 2010 both found a significant reduction in adjusted relative risk of ovarian and endometrial cancer mortality in ever-users of OCs compared with never-users.
The use of oral contraceptives (birth control pills) for five years or more decreases the risk of ovarian cancer in later life by 50%. Combined oral contraceptive use reduces the risk of ovarian cancer by 40% and the risk of endometrial cancer by 50% compared with never users. The risk reduction increases with duration of use, with an 80% reduction in risk for both ovarian and endometrial cancer with use for more than 10 years. The risk reduction for both ovarian and endometrial cancer persists for at least 20 years.
Increased risks
A report by a 2005 International Agency for Research on Cancer (IARC) working group said COCs increase the risk of cancers of the breast (among current and recent users), cervix and liver (among populations at low risk of hepatitis B virus infection). A 2013 meta-analysis concluded that every use of birth control pills is associated with a modest increase in the risk of breast cancer (relative risk 1.08) and a reduced risk of colorectal cancer (relative risk 0.86) and endometrial cancer (relative risk 0.57). Cervical cancer risk in those infected with human papilloma virus is increased. A similar small increase in breast cancer risk was seen in other meta analyses.
Combined oral contraceptive pill
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